Understanding telomere diseases through analysis of patient-derived iPS cells
نویسندگان
چکیده
منابع مشابه
Understanding the mysteries of iPS cells
The development of induced pluripotent stem (iPS†) cells is one of the newest and most exciting areas of stem cell research. Takahashi and Yamanaka, in a landmark paper in 2006 [1], were able to demonstrate that cultured and fully differentiated mouse fibroblasts could be transformed into pluripotent embryonic-like stem cells able to produce all three germ layers in addition to chimeric animals...
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Telomere reprogramming and silencing of exogenous genes have been demonstrated in mouse and human induced pluripotent stem cells (iPS cells). Pigs have the potential to provide xenotransplant for humans, and to model and test human diseases. We investigated the telomere length and maintenance in porcine iPS cells generated and cultured under various conditions. Telomere lengths vary among diffe...
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David M Gamm, Department of Ophthalmology and Visual Sciences, McPherson Eye Research Institute, Waisman Center Stem Cell Research Program, University of Wisconsin School of Medicine and Public Health, Waisman Center, Room T609, 1500 Highland Ave, Madison, WI 53705, USA M Joseph Phillips, and Waisman Center Stem Cell Research Program, University of Wisconsin School of Medicine and Public Health...
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Reprogramming of somatic cells to an embryonic-like state has dramatically changed the landscape of stem cell research. Although still in its formative stages, the field of induced pluripotent stem cells (iPSCs) has the potential to advance the study of neurodegenerative and neurodevelopmental disorders at the molecular and cellular levels. The iPSC technology could be employed to establish in ...
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Cellular reprogramming of somatic cells to human pluripotent stem cells (iPSC) represents an efficient tool for in vitro modeling of human brain diseases and provides an innovative opportunity in the identification of new therapeutic drugs. Patient-specific iPSC can be differentiated into disease-relevant cell types, including neurons, carrying the genetic background of the donor and enabling d...
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ژورنال
عنوان ژورنال: Current Opinion in Genetics & Development
سال: 2013
ISSN: 0959-437X
DOI: 10.1016/j.gde.2013.07.006